Antigen-specific CD4 T cells regulate function of myeloid-derived suppressor cells in cancer via retrograde MHC class II signaling MDSC and CD4 T cells Myeloid-derived suppressor cells, T cells, immune tolerance
نویسندگان
چکیده
† H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612 Departments of Internal and Molecular Medicine, University of South Florida, Tampa, FL, 33612 Address for correspondence: Srinivas Nagaraj: [email protected]; Ph:813-974-4585, FAX: 813-905-9913 or Dmitry Gabrilovich, H. Lee Moffitt Cancer Center 12902 Magnolia Dr., Tampa, FL, 33612; [email protected]; Ph: 813-745-6863, FAX: 813-745-1328
منابع مشابه
Regulatory T Cells and Myeloid-Derived Suppressor Cells in Patients with Peptic Ulcer and Gastric Cancer
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection, and together with regulatory T cells (Tregs) have a remarkable ability to suppress immune responses. The phenotype of MDSCs differs in humans and mice, and the exact mechanisms of their suppressive function are still controversially discussed. Limited data are...
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